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Candia 5 Home Candida Test

candia5.jpegCandida Rapid Test

CanDia5® Is the world’s first and only blood based professional home test for candidiasis. This accurate test utilises just a small drop of whole blood taken from a finger stick to provide accurate diagnosis within 5 minutes.

This is a test I highly recommend if you want to know if you have candida or not, it is an easy to use test kit which will accurately test for the detection of candidiasis. CanDia5 is the only known test which can accurately detect the presence of not only candida albicans, but for antibodies of the four common candida species C.albicans, C.glabrata, C.tropicalis and C.parapsiloiss

Why a blood test for candida?

With this amazing test, you will be able to tell within 5 minutes if you have a candida albicans yeast infection or not, it's that simple. You will be able to diagnose candidiasis infections to help determine the most appropriate treatment, and after treatment you will be able to confirm effectiveness or continued need for treatment (re-test after 3 months if required). Comprehensive, easy to follow instructions are provided with this kit.

The Candia 5 test is 90% specific to candida, and is the world's leading home candida test, there is NO better test than this. This test does not test for candida itself, but rather the antibodies created by your immune system after they have detected this little fungus and have prepared to mount a defence (antibody production) to counter it.

Candida albicans is a yeast or fungus which is always present in the intestinal and genital tracts, even in healthy people. But, if the candida proliferation becomes disproportionate to the other 400 or so 'friendly' bacteria strains in the intestine, it becomes candidiasis - a candida infection.

Candidiasis can also become Systemic Candidiasis, and affect the whole body. This is a serious infection which may require rapid medical intervention. Oral and vaginal thrush, jock itch and infant diaper rash are the most commonly recognised symptoms of candidiasis, however, candida infections may manifest in many different areas of the body. The signs and symptoms of candida yeast infections are many and varied, from a white coated tongue, skin and vaginal itching or burning, irritable bowel and cystitis to bad breath, PMS, joint pain and extreme fatigue. Because of its many disguises and symptoms, candidiasis is often overlooked or misdiagnosed.

Candidiasis may affect anyone at any age and is easily transmitted through intimate contact such as sexual intercourse and even by breastfeeding mothers to their children. With candida albicans yeast infections, the effects and causes can be varied

Factors that increase susceptibility to candida infections include immune weakness, antibiotic use, contraceptive pills and steroidal drugs. Because candidiasis can damage the intestinal lining and disrupt the immune system, people with candida infections often also have or develop food allergies and intolerances. Used by doctors, hospitals and natural health practitioners internationally, CanDia5 is the only candida diagnosis test of its kind.

CanDia5 is now available to you as an affordable, non-invasive way to accurately diagnose candida infections without the need for a doctor's appointment or a full blood test.

Candia5_Logo.jpg


Special features of the Candia 5 test

  • High performance
  • Instantaneous
  • Highly accurate
  • Reliable results 
  • Analysis time within 5 minutes
  • Tiny drop of patient's blood required
  • A 78 percent rate of sensitivity 
  • A 90 percent rate of specificity

Candia 5 Kit Contents & Instructions

  • Finger prick blood test kit includes: CanDia5 test device, one sample applicator, chase buffer solution, retractable safety lancet and an alcohol swab.
  • Wear gloves when performing the test, use only as directed.


Very Accurate Test

CanDia5 has been tested for accuracy and reproducibility and has shown a high level of consistent accuracy, achieving a 95% Positive Predictive Value score (PPV). This level of PPV makes CanDia5 the most accurate diagnostic tool available for candida.

Pregnant_12.jpgCandida Pregnancy Testing

The test is indicated as a screening test during pregnancy. This is because women are at high risk of developing VVC during the pregnancy and it is known that VVC during pregnancy is significantly associated with Intrauterine Growth Retardation. Recent evidence has also shown that screening and treatment of VVC during pregnancy may significantly reduce the prevalence of preterm labour.

Between 5% and 10% of healthy women of reproductive age may suffer from recurrent VVC. This is defined in the medical literature as 4 -5 infections per year. Since symptoms of VVC are usually non specific, it is important to ensure that accurate diagnosis is performed before embarking on a course of treatment.

possible® is a lateral flow assay which requires five simple steps in order to perform accurate diagnosis. All of the accessories required to perform the test are included within the box, along with instructions which are easy to follow.


Candida_Albicans_12.gifFrequently Asked Questions

The following is a list of the most common questions asked when discussing Candida testing. Up until recently, it was not really posible to test for candida theicans in teh privacy of your own home, today it is. Perhaps you may have a question relating to this test? Then you will probably find the answer right here.

 

 

 

FAQ - 1. Everybody has Candida so this test will be positive for everyone who is a carrier. Can it differentiate between carriers (commensal carriage) and infection?

  • Approximately 75% of the population carries Candida asymptomatically (without any signs of symptoms), therefore a large part of the population are carriers.
  • Most people are colonised (usually in the mouth, vagina and gastrointestinal tract) by Candida.  So we are exposed to Candida antigens from birth. 
  • The surface of the Candida organism is covered by proteins which have had mannose sugars attached to them.  The mannose portion of these mannoproteins is highly immunogenic, so most healthy people will have antibodies against mannose due to the constant exposure of the mucosal surfaces of the GI tract and vagina to the Candida organism.
  • However, the internal cytoplasmic antigens of Candida are only released when there is an active infection and the Candida organism is being broken open by the host’s innate immune defences (Neutrophils and Macrophages).By using these antigens in our Candida test we measure only antibodies produced in response to infection not commensal carriage.
  • Commensal = beneficial partnership between 2 organisms
  • Commensal carriage = organisms carried within body as part of the normal flora in a harmless manner
  • Asymptomatic = absence of symptoms
  • Colonisation = inhabitation
N.B: Asymptomatic colonisation & commensal carriage are used interchangeably.
FAQ - 2. You don’t need a test to diagnose Candida. You just need to have a look!  (in case of thrush)
The test is recommended for the following scenarios:
  • A patient with vulval pain & no other symptoms,
  • A patient with an itch but no other symptoms
  • A patient who is convinced that they have an infection but the doctor knows that they do not (i.e. to convince the patient)
  • To differentiate between bacterial & fungal infection (as the signs & symptoms can be the same for both)
  • Most doctors will tell you that they can diagnose thrush without a problem and this is true for the patient with the classical symptoms of:
    • Itch
    • Cottage cheese-like discharge
    • Inflamed vagina
  • We are recommending that the test be used for the not so ‘clear-cut’ cases listed above.
FAQ - 3. If I am not sure what is causing the infection, I just prescribe for all 3 possibilities.
There are 3 possibilities where infection is concerned:
  • Bacterial (most common ~ 50%)
  • Fungal = Candida ~ 25%
  • Protozoal ( more common in sexual health clinics) ~ 15%
  • There are doctors who will take the irresponsible approach and just prescribe 3 treatments because:
    • They average 5-6 minute consultations (N.B. For us to know only)
    • They do not have time for tests

FAQ - 4. Will this test pick up a superficial infection?
Yes. Regardless of where in the body the infection is occurring this test will pick it up as it is detecting Antibodies produced in response to the infection.
  • The infection can be:
    • Superficial (surface skin lesions)
    • Invasive Candidiasis ( defined by the CDC as a bloodstream infection by the organism that is disseminated throughout the body)
    • Systemic (usually multiple organ involvement, whole body response to severely compromised immune system)
    • Oral
    • Gastrointestinal
    • Vaginal

 5. Does the test differentiate where the infection has originated?
No. The healthcare professional has to take a full clinical history & determine this for themselves.
  • The test will, however, aid in eliminating the 2 other possible causes (ie: bacterial & protozoal)
  • The test gives you a clear positive or negative, that is, it tells you whether the patient has a current (active) infection.

6. I am surprised you are using blood!
That is because GP’s are used to taking vaginal swabs.
  • A swab does not differentiate between infection & colonised carriage because the cotton swab is sampling the surface of the vaginal wall. This is one of the areas sanitised by Candida (refer to point 1.)
  • Furthermore, if the patient has used a vaginal pessary or a douche then the area will have been sanitized and a swab will return negative as the numbers are too low for detection.
    • Pessary = medicated appliance for insertion into the vagina for treatment purposes
    • Douche = thorough washing of the vagina
  • During an infection the body produces antibodies as part of its defence mechanism. These antibodies are different from those produced initially when a host is first exposed usually at birth (refer to point 1.).
  • Therefore we can pick up these antibodies as they circulate freely in blood.

7. Why are you detecting IgG antibodies instead of IgM antibodies? IgM appear first.
  • IgM produced during the primary immune response (released after primary antigenic stimulation). This happens the very first time a host is exposed. This is usually at birth during passage through the birth canal.
  • IgG response is high & immediate after a second infection.
  • A large percentage of the population has been exposed from birth therefore IgG antibody levels will be much higher then IgM. They will also be sustained a lot longer in the body and therefore easier to detect. (See diagram below )
candida graph.jpg










  • Characteristics of the primary (1°) exposure / response:
  • Slow response
  • IgM predominates over localised
  • Low  amount and short lasting
  • Characteristics of the Secondary (2°) exposure / response:
  • Faster and more effective than primary response 
  • Larger amounts are produced, and these last longer.

8. Our pathology provider does an Antigen test and this is sensitive enough.
This is not true. Although antigens do appear first they have a very short lifespan. They are cleared from the body very quickly by the bodies defence mechanism.
  • Antigens do not circulate freely like antibodies. Antigens remain hospitalised the area of infection.
  • Most patients do not go to the doctor until symptoms appear by which stage the antigens have cleared and antibodies are being produced.

9. How does the test detect Candida?
  • It does not detect Candida the organism. The organism does not circulate in the blood except in the severely compromised. (These patients will be hospitalized in ICU)
  • The test detects antibodies produced in response to an active infection Refer to point 1.).

10. How long does a patient remain Antibody positive?
  • We believe the response lasts approximately 3 months.
  • The current clinical trial is designed to provide scientific data to answer this question.

References

  1. Kiss, H., et al (2004), Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery:BMJ 329 371-374.
  2. Vazquez, J. A., and J. D. Sobel. Fungal infections in diabetes. Infectious Diseases Clinics of North America, March 1995; Volume 9: 97-116.
  3. Duerr, A., M. F. Sierra, J. Feldman, L. M. Clarke, I. Ehrlich, and J. DeHovitz. Immune compromise and prevalence of Candida vulvovaginitis in human immunodeficiency virus-infected women. Obstetrics & Gynecology, 1997; Volume 90: 252-256. .
  4. Otero, L., V. Palacio, F. Carreño, F. J. Méndez, and F. Vázquez. Vulvovaginal candidiasis in female sex workers. International Journal of STD & AIDS, 1998; Volume 9: 526-530.
  5. Sobel, J. D., S. Faro, R. W. Force, B. Foxman, W. J. Ledger, P. R. Nyirjesy, B. D. Reed, and P. R. Summers. Vulvovaginal candidiasis: Epidemiological, diagnostic, and therapeutic considerations. American Journal of Obstetrics and Gynecology, February 1998; Volume 178, Number 2: 203-211.
  6. Ferrer, J.. Vaginal candidiasis: epidemiological and etiological factors. International Journal of Gynecology & Obstetrics, 2000; Volume 71: S21-S27.
  7. Paavonen J, Stamm WE. Sexually transmitted diseases: lower genital tract infections in women. Infect Dis Clin North Am 1987;1(1):179-98
  8. Paavonen J, Stamm WE. Sexually transmitted diseases: lower genital tract infections in women. Infect Dis Clin North Am 1987;1(1):179-98
  9. Foxman, B et al. Candida Vaginitis. Self-Reported Incidence and Associated Cost. Sexually Transmitted Disease, April 2000;Volume 27, No 4:230-235.
  10. Bergman, J. J, A. O. Berg, R. Schneeweiss, and F. E. Heidrich. Clinical comparison of microscopic and culture techniques in the diagnosis of Candida vaginitis. The Journal of Family Practice, 1984; Volume 18: 549-552.
  11. DoctorFungus Corporation. Candidiasis: Overview and full index. Retrieved 11 June 2002, from http://www.doctorfungus.org/mycoses/human/candida/Vulvovaginal.htm.
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